Pub. Date : 2019 Apr
PMID : 30689265
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Furthermore, apoptosis and autophagy were increased in multidrug resistance protein 1 knockout HMM cells cultured under glucose starvation with metformin treatment. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The data suggest that mitochondrial Mdr1 plays a critical role in the chemoresistance to metformin in HMM cells, which could be a potential target for improving its therapeutic efficacy. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |