Pub. Date : 2019 Jul 1
PMID : 30679163
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |
| 2 | We determined the mechanistic role of LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) in cancer cell survival under oxygen-glucose deprivation conditions. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |
| 3 | We determined the mechanistic role of LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) in cancer cell survival under oxygen-glucose deprivation conditions. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |
| 4 | Increased LIMS1 expression was pivotal for tumor cells to survive in the oxygen-glucose deprivation conditions. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |
| 5 | Furthermore, LIMS1 promoted HIF1A protein translation by activating AKT/mTOR signaling, while hypoxia-inducible factor 1 (HIF1) transactivated LIMS1 transcription, thus forming a positive feedback loop in PDAC cell adaptation to oxygen deprivation stress. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |
| 6 | CONCLUSIONS: LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by activating AKT/mTOR signaling and enhancing HIF1A protein translation. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |
| 7 | LIMS1 is crucial for tumor adaptation to oxygen-glucose deprivation conditions and is a promising therapeutic target for cancer treatment. | Oxygen | LIM zinc finger domain containing 1 | Homo sapiens |