Title : Bioenergetic modulation with the mitochondria uncouplers SR4 and niclosamide prevents proliferation and growth of treatment-naïve and vemurafenib-resistant melanomas.

Pub. Date : 2018 Dec 11

PMID : 30651927






1 Functional Relationships(s)
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1 These results suggest that uncouplers such as SR4 and niclosamide may be useful as first line treatment against melanoma regardless of BRAF/NRAS status, and as an adjuvant therapy for patients failing MAPK inhibitors. Niclosamide B-Raf proto-oncogene, serine/threonine kinase Homo sapiens