Title : Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity.

Pub. Date : 2019 Mar

PMID : 30651583






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The accumulated intracellular BAs activate SRC kinase via the TGR5-GRK-beta-arrestin axis, which mediates tyrosine phosphorylation of multiple antiviral signaling components including RIG-I, VISA/MAVS, MITA/STING, TBK1 and IRF3. Tyrosine Rous sarcoma oncogene Mus musculus
2 The tyrosine phosphorylation of these components by SRC conditions for efficient innate antiviral immune response. Tyrosine Rous sarcoma oncogene Mus musculus