Pub. Date : 2019 Jan 15
PMID : 30650352
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1. | Poly Adenosine Diphosphate Ribose | X-ray repair cross complementing 1 | Homo sapiens |
| 2 | XRCC1 itself is recruited to DNA damage through interaction of its central BRCT domain with poly(ADP-ribose) chains generated by PARP1 or PARP2. | Poly Adenosine Diphosphate Ribose | X-ray repair cross complementing 1 | Homo sapiens |
| 3 | We now show that the central BRCT domain simultaneously mediates interaction of XRCC1 with poly(ADP-ribose) and DNA, through separate and non-overlapping binding sites on opposite faces of the domain. | Poly Adenosine Diphosphate Ribose | X-ray repair cross complementing 1 | Homo sapiens |