| Protein Name | X-ray repair cross complementing 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7515 |
| Gene Symbol | XRCC1 |
| UniProt | P18887 (XRCC1_HUMAN), B2RCY5 (B2RCY5_HUMAN), Q59HH7 (Q59HH7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
281
Total Number of Articles : 580 |
Description |
X-ray repair cross complementing 1 |
| Gene Summary |
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] |
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