Protein Name X-ray repair cross complementing 1
Organism Homo sapiens
Gene ID 7515
Gene Symbol


UniProt P18887 (XRCC1_HUMAN), B2RCY5 (B2RCY5_HUMAN), Q59HH7 (Q59HH7_HUMAN)
Relationships Total Number of functionally related compound(s) : 281
Total Number of Articles : 580

X-ray repair cross complementing 1

Gene Summary

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

  • DNA repair protein XRCC1
  • X-ray repair complementing defective repair in Chinese hamster cells 1
  • X-ray repair cross-complementing protein 1
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