Title : Metformin counteracts glucose-dependent lipogenesis and impairs transdeamination in the liver of gilthead sea bream ( Sparus aurata).

Pub. Date : 2019 Mar 1

PMID : 30649892






1 Functional Relationships(s)
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1 Hyperglycemia markedly upregulated the expression of glycolytic enzymes (glucokinase and 6-phosphofructo-1-kinase, PFK1) 5 h following glucose administration, while at 24 h posttreatment, it increased isocitrate dehydrogenase (IDH) activity, a key enzyme of the tricarboxylic acid cycle, and the expression of lipogenic factors (PGC1beta, Lpin1, and SREBP1). Glucose isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens