Title : The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.

Pub. Date : 2019 Apr 4

PMID : 30642920






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 D1 and D2 in the prodomain and D"D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. Disulfides von Willebrand factor Homo sapiens
2 D1 and D2 in the prodomain and D"D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. Disulfides von Willebrand factor Homo sapiens
3 The organizing principle for the D3 assembly has implications for other D assemblies and the construction of higher-order, disulfide-linked assemblies in the Golgi in both VWF and mucins. Disulfides von Willebrand factor Homo sapiens