Pub. Date : 2019 Mar 31
PMID : 30639533
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Alternatively, through drug repositioning of approved drugs, we discovered that the FMS-like tyrosine kinase-3 (FLT3) inhibitor midostaurin blocks the drug transport function of ABCB1 and re-sensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic drugs. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Alternatively, through drug repositioning of approved drugs, we discovered that the FMS-like tyrosine kinase-3 (FLT3) inhibitor midostaurin blocks the drug transport function of ABCB1 and re-sensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic drugs. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Our findings were further supported by results demonstrating that midostaurin potentiates drug-induced apoptosis in ABCB1-overexpressing cancer cells and inhibits the ATPase activity of ABCB1. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Our findings were further supported by results demonstrating that midostaurin potentiates drug-induced apoptosis in ABCB1-overexpressing cancer cells and inhibits the ATPase activity of ABCB1. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |