Title : Formulating a single thioether-bridged oleate prodrug into a self-nanoemulsifying drug delivery system to facilitate oral absorption of docetaxel.

Pub. Date : 2019 Feb 26

PMID : 30638237






5 Functional Relationships(s)
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Protein Name
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1 Oral chemotherapy of docetaxel (DTX) is restricted by active P-glycoprotein (P-gp) efflux, hepatic first-pass metabolism and then poor oral absorption. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens
2 Oral chemotherapy of docetaxel (DTX) is restricted by active P-glycoprotein (P-gp) efflux, hepatic first-pass metabolism and then poor oral absorption. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens
3 Oral chemotherapy of docetaxel (DTX) is restricted by active P-glycoprotein (P-gp) efflux, hepatic first-pass metabolism and then poor oral absorption. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens
4 Oral chemotherapy of docetaxel (DTX) is restricted by active P-glycoprotein (P-gp) efflux, hepatic first-pass metabolism and then poor oral absorption. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens
5 Moreover, DTX-S-OA showed a comparable ability with verapamil in inhibiting P-gp efflux. Docetaxel ATP binding cassette subfamily B member 1 Homo sapiens