Pub. Date : 2019 Mar
PMID : 30633982
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1alpha/JNK signaling and nuclear Nrf2 activation. | Acetylcysteine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Simultaneously, NAC pretreatment downregulated XBP1 splicing, reduced JNK phosphorylation and further blocked cleavage of caspase-3, all these might contribute to the inhibition of testicular cell apoptosis. | Acetylcysteine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Collectively, the present results suggested that prolonged administration of NAC preserved testicular function and normalized sex hormonal disruption induced by NaF via the inhibition of Nrf2-associated oxidative damage and Ire1alpha-JNK-mediated apoptosis in rat testis. | Acetylcysteine | mitogen-activated protein kinase 8 | Rattus norvegicus |