Pub. Date : 2019
PMID : 30632799
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tramadol induces changes in Delta-FosB, micro-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat. | Tramadol | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | RESULTS: In the NAC, acute tramadol exposure increases the levels of MOR and p-CREB. | Tramadol | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | Moreover, chronic tramadol administration in this region results in elevated levels of MOR, DeltaFosB and p-CREB compared with saline-treated rats. | Tramadol | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | The levels of MOR and p-CREB in the PFC increased in both acute and chronic tramadol exposure. | Tramadol | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 5 | CONCLUSION: We concluded that both CREB and DeltaFosB played a role in tramadol dependence. | Tramadol | cAMP responsive element binding protein 1 | Rattus norvegicus |