Title : Tolerance-based capecitabine dose escalation after DPYD genotype-guided dosing in heterozygote DPYD variant carriers: a single-center observational study.

Pub. Date : 2019 Apr

PMID : 30628914






1 Functional Relationships(s)
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1 OBJECTIVE: Certain polymorphisms of the DPYD gene encoding for the dihydropyrimidine dehydrogenase (DPD) enzyme are associated with fluoropyrimidine-induced toxicity. dihydropyrimidine dihydropyrimidine dehydrogenase Homo sapiens