Title : Current status of PI3K-mTOR inhibition in hormone-receptor positive, HER2-negative breast cancer.

Pub. Date : 2018 Dec 20

PMID : 30622925






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1 Inhibitors of the mTOR have been tested in different clinical trials; everolimus has been Food and Drug Administration approved for the treatment of oestrogen receptor positive/human epidermal growth factor receptor 2 negative BC patients in combination with exemestane in patients who have progressed to anastrozole or letrozole after the encouraging results coming from BOLERO-2 trial. exemestane mechanistic target of rapamycin kinase Homo sapiens