Pub. Date : 2019 Sep
PMID : 30615306
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta-analysis. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 2 | This meta-analyses reviewed all available studies on associations between metformin use and vitamin B12 levels, anemia, and neuropathy in diabetic patients. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 3 | Compared with diabetic patients not taking metformin, patients taking metformin had a significantly higher risk of vitamin B12 deficiency (RR 2.09; 95% CI 1.49, 2.93; P < 0.0001; I2 = 64%) and significantly lower serum vitamin B12 concentrations (MD -63.70; 95% CI -74.35, -53.05] pM; P < 0.00001; I2 = 87%), which depended on dose and duration of treatment. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 4 | Compared with diabetic patients not taking metformin, patients taking metformin had a significantly higher risk of vitamin B12 deficiency (RR 2.09; 95% CI 1.49, 2.93; P < 0.0001; I2 = 64%) and significantly lower serum vitamin B12 concentrations (MD -63.70; 95% CI -74.35, -53.05] pM; P < 0.00001; I2 = 87%), which depended on dose and duration of treatment. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 5 | Metformin use was also associated with significantly greater percentage decrease in serum vitamin B12 concentrations from baseline in diabetic patients (MD -14.68%; 95% CI -17.98%, -11.39%; P < 0.00001; I2 = 33%). | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 6 | CONCLUSIONS: Metformin use led to significantly lowered vitamin B12 concentrations and significantly higher risk of vitamin B12 deficiency in diabetic patients. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 7 | CONCLUSIONS: Metformin use led to significantly lowered vitamin B12 concentrations and significantly higher risk of vitamin B12 deficiency in diabetic patients. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 8 | Annual vitamin B12 assessment in diabetic patients taking metformin is recommended. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |