Title : Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells.

Pub. Date : 2019 Feb 15

PMID : 30611723






3 Functional Relationships(s)
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1 In OA-loaded HepaRG cells, FOH increased fatty acid oxidation, which was accompanied by up-regulation of PPARalpha target genes involved in mitochondrial fatty acid oxidation, including hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase and acetyl-coenzyme A acyltransferase 2. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
2 These findings show that FOH treatment increases fatty acid oxidation and decreases TG accumulation in steatotic HepaRG cells, which is likely attributable to PPARalpha-mediated induction of mitochondrial fatty acid oxidation. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
3 These findings show that FOH treatment increases fatty acid oxidation and decreases TG accumulation in steatotic HepaRG cells, which is likely attributable to PPARalpha-mediated induction of mitochondrial fatty acid oxidation. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens