Title : Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling.

Pub. Date : 2019 Mar

PMID : 30609217






1 Functional Relationships(s)
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1 Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation. ursolic acid thymoma viral proto-oncogene 1 Mus musculus