Title : Exploring the interaction between epidermal growth factor receptor tyrosine kinase and some of the synthesized inhibitors using combination of in-silico and in-vitro cytotoxicity methods.

Pub. Date : 2018 Dec

PMID : 30607149






2 Functional Relationships(s)
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1 Based on the results, the compounds L1, L2, L4, L5, L6, L7, L10, L15, and L18 may be promising EGFR inhibitors based on docking score and hydrogen bonds. Hydrogen epidermal growth factor receptor Homo sapiens
2 The results indicated that the three compounds bound to EGFR active site in a stable manner during the simulation through the formation of new hydrogen bonds with Phe699, Leu694, Gly700, Lys721, Met769, Arg817, and Asp831 with the superiority of compound L15. Hydrogen epidermal growth factor receptor Homo sapiens