Pub. Date : 2019 Mar
PMID : 30606762
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endothelial Cell-Targeted Deletion of PPARgamma Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | Compared with Pparg-floxed wild-type control (Pparg f/f) mice, Pparg DeltaEC treated with rosiglitazone are resistant to an increase in extracellular fluid, water content in epididymal and inguinal white adipose tissue, and plasma volume expansion. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | Compared with Pparg-floxed wild-type control (Pparg f/f) mice, Pparg DeltaEC treated with rosiglitazone are resistant to an increase in extracellular fluid, water content in epididymal and inguinal white adipose tissue, and plasma volume expansion. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | Compared with Pparg-floxed wild-type control (Pparg f/f) mice, Pparg DeltaEC treated with rosiglitazone are resistant to an increase in extracellular fluid, water content in epididymal and inguinal white adipose tissue, and plasma volume expansion. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | Interestingly, histologic assessment confirmed significant rosiglitazone-mediated capillary dilation within white adipose tissue of Pparg f/f mice, but not Pparg DeltaEC mice. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 6 | Together, these results indicate that rosiglitazone has direct effects on the endothelium via PPARgamma activation and point toward a critical role for PPARgamma in ECs during rosiglitazone-mediated plasma volume expansion. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 7 | Together, these results indicate that rosiglitazone has direct effects on the endothelium via PPARgamma activation and point toward a critical role for PPARgamma in ECs during rosiglitazone-mediated plasma volume expansion. | Rosiglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |