Title : Spatial Cycling of Rab GTPase, Driven by the GTPase Cycle, Controls Rab's Subcellular Distribution.

Pub. Date : 2019 Jan 29

PMID : 30605611






1 Functional Relationships(s)
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1 We demonstrate that the switching between GTP and GDP binding states, which is governed by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), GDI, and GDI displacement factor (GDF), is a major determinant of Rab1"s ability to effectively cycle between cellular compartments and eventually its subcellular distribution. Guanosine Triphosphate RAB1A, member RAS oncogene family Homo sapiens