Pub. Date : 2019 Feb 14
PMID : 30602573
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Background: Reversal of alcohol-induced peroxisome proliferator-activated receptor (PPAR) alpha (PPARalpha) and PPARdelta dysfunction has been reported to decrease the severity of alcoholic steatohepatitis (ASH). | Alcohols | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Background: Reversal of alcohol-induced peroxisome proliferator-activated receptor (PPAR) alpha (PPARalpha) and PPARdelta dysfunction has been reported to decrease the severity of alcoholic steatohepatitis (ASH). | Alcohols | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Results: C57BL/6 mice on ethanol diet showed AT dysfunction, disrupted intestinal barrier, and ASH, which was accompanied by alcohol-mediated decrease in PPARalpha, PPARdelta, and autophagy levels in intestine, liver, and AT. | Alcohols | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | Conclusion: Altogether, these findings demonstrated that the PPARalpha/delta agonist, elafibranor, decreased the severity of liver injury by restoration of alcohol-suppressed AT autophagy function and by decreasing the release of apoptotic markers, inflammatory cytokines, and FFA, thereby reducing intestinal epithelium disruption and liver inflammation/apoptosis/steatosis in ASH mice. | Alcohols | peroxisome proliferator activated receptor alpha | Mus musculus |