Title : Celastrol-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis.

Pub. Date : 2019 Jan 29

PMID : 30601470






2 Functional Relationships(s)
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1 In this work, the hydrophobic small molecule NF-kappaB inhibitor celastrol was loaded into poly(ethylene glycol)-b-poly(propylene sulfide) (PEG-b-PPS) micelles. celastrol nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Encapsulation of celastrol within these nanocarriers significantly reduced cytotoxicity compared to free celastrol, while simultaneously expanding the lower concentration range for effective inhibition of NF-kappaB signaling by nearly 50 000-fold. celastrol nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus