Title : Identification of BR101549 as a lead candidate of non-TZD PPARĪ³ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.

Pub. Date : 2019 Feb 15

PMID : 30594432






1 Functional Relationships(s)
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1 The X-ray crystallography of BR101549 with PPARgamma ligand binding domain (LBD) revealed unique binding characteristics versus traditional TZD full agonists. tzd peroxisome proliferator activated receptor gamma Mus musculus