Pub. Date : 2019 May 1
PMID : 30590679
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously showed that mammalian HP1alpha is constitutively phosphorylated at its N-terminal serine residues by casein kinase II (CK2), and that this phosphorylation enhances HP1alpha"s binding specificity for nucleosomes containing lysine 9-methylated histone H3 (H3K9me). | Serine | chromobox 5 | Homo sapiens |
| 2 | Although HP1"s mitotic behaviour was previously linked to H3 serine 10 phosphorylation, which blocks the binding of HP1"s chromodomain to H3K9me3, our findings suggest that mitotic phosphorylation in HP1alpha"s hinge region also contributes to changes in HP1alpha"s association with mitotic chromatin. | Serine | chromobox 5 | Homo sapiens |
| 3 | Although HP1"s mitotic behaviour was previously linked to H3 serine 10 phosphorylation, which blocks the binding of HP1"s chromodomain to H3K9me3, our findings suggest that mitotic phosphorylation in HP1alpha"s hinge region also contributes to changes in HP1alpha"s association with mitotic chromatin. | Serine | chromobox 5 | Homo sapiens |