| Protein Name | chromobox 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 23468 |
| Gene Symbol | CBX5 |
| UniProt | P45973 (CBX5_HUMAN), V9HWG0 (V9HWG0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
145
Total Number of Articles : 199 |
Description |
chromobox 5 |
| Gene Summary |
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
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| Properties | |