Title : 17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor.

Pub. Date : 2019 Mar 15

PMID : 30590021






2 Functional Relationships(s)
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1 Furthermore, GPR30 antagonist pre-treatment inhibited increases in NETosis and PAD4 expression mediated by G-1 and partially inhibited these effects mediated by E2. Estradiol G protein-coupled estrogen receptor 1 Homo sapiens
2 These results demonstrate that E2 treatment induces NETosis via not only ERalpha/ERbeta but also GPR30 in neutrophil-like HL-60 cells. Estradiol G protein-coupled estrogen receptor 1 Homo sapiens