Pub. Date : 2019 Apr 15
PMID : 30589193
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective Delivery of Doxorubicin to EGFR+ Cancer Cells by Cetuximab-DNA Conjugates. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 2 | Cytotoxicity and flow cytometry data showed that doxorubicin loaded in cetuximab-DNA conjugates was more potent in terms of cell cytotoxicity than free doxorubicin in EGFR-overexpressed cell lines, thus suggesting that the conjugates were more selectively and easily taken up into cells, followed by rapid release of doxorubicin from the system into the cytoplasm from endosomes. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 3 | Cytotoxicity and flow cytometry data showed that doxorubicin loaded in cetuximab-DNA conjugates was more potent in terms of cell cytotoxicity than free doxorubicin in EGFR-overexpressed cell lines, thus suggesting that the conjugates were more selectively and easily taken up into cells, followed by rapid release of doxorubicin from the system into the cytoplasm from endosomes. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 4 | Cytotoxicity and flow cytometry data showed that doxorubicin loaded in cetuximab-DNA conjugates was more potent in terms of cell cytotoxicity than free doxorubicin in EGFR-overexpressed cell lines, thus suggesting that the conjugates were more selectively and easily taken up into cells, followed by rapid release of doxorubicin from the system into the cytoplasm from endosomes. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |