Title : Noteworthy effect of slight variation in aliphatic chain length of trisubstituted imidazole inhibitors against epidermal growth factor receptor L858R/T790M/C797S mutant in cancer therapy.

Pub. Date : 2019 May

PMID : 30582282






1 Functional Relationships(s)
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1 11h is a very potent inhibitor against epidermal growth factor receptor triple mutation L858R/T790M/C797S (EGFRTM ) with 13-fold stronger potency than the FDA-approved osimertinib. osimertinib epidermal growth factor receptor Homo sapiens