Title : Docosahexaenoic acid-thyroid hormone combined protocol as a novel approach to metabolic stress disorders: Relation to mitochondrial adaptation via liver PGC-1α and sirtuin1 activation.

Pub. Date : 2019 Mar

PMID : 30578580






2 Functional Relationships(s)
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1 Combined DHA + T3 protocol led to increased liver AMPK, PGC-1alpha, NRF-2, COX-IV, and beta-ATP synthase mRNAs, with concomitant higher protein levels of COX-IV and NRF-2, 369% enhancement in the NAD+ /NADH ratio, 47% decrease in histone 3 acetylation and 162% increase in serum levels of beta-hydroxybutyrate over control values. Docosahexaenoic Acids NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 Combined DHA + T3 protocol led to increased liver AMPK, PGC-1alpha, NRF-2, COX-IV, and beta-ATP synthase mRNAs, with concomitant higher protein levels of COX-IV and NRF-2, 369% enhancement in the NAD+ /NADH ratio, 47% decrease in histone 3 acetylation and 162% increase in serum levels of beta-hydroxybutyrate over control values. Docosahexaenoic Acids NFE2 like bZIP transcription factor 2 Rattus norvegicus