Title : KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons.

Pub. Date : 2019 Mar

PMID : 30557564






3 Functional Relationships(s)
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1 Since manganese superoxide dismutase (MnSOD) is the main mechanism to detoxify mitochondrial superoxide radicals, the cause and effect relationship between improved respiration and decreased oxidative stress was examined after knocking down MnSOD. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
2 Since manganese superoxide dismutase (MnSOD) is the main mechanism to detoxify mitochondrial superoxide radicals, the cause and effect relationship between improved respiration and decreased oxidative stress was examined after knocking down MnSOD. Superoxides superoxide dismutase 2, mitochondrial Mus musculus
3 Downregulating MnSOD in diabetic WT neurons increased hyperglycemia-induced superoxide levels, which was still significantly decreased by KU-596. Superoxides superoxide dismutase 2, mitochondrial Mus musculus