Title : Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone.

Pub. Date : 2019 Jan 15

PMID : 30553624






1 Functional Relationships(s)
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1 Structural evolution of 37 produced the azide-containing cis-49a, which had good properties in three important respects: (1) selectivity for CYP1B1 over CYP1A1 and CYP1A2 (120-times and 150-times, respectively), (2) greater inhibitory potency of >2 times that of ANF, and (3) improved solubility. Azides cytochrome P450 family 1 subfamily A member 2 Homo sapiens