Pub. Date : 2019 Feb 10
PMID : 30553002
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice. | quizartinib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice. | quizartinib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | Quizartinib was transported by human ABCB1 in vitro, and by mouse (m)Abcb1 and mAbcg2 in vivo. | quizartinib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | Upon oral administration, the brain accumulation of quizartinib was 6-fold decreased by mAbcb1 and 2-fold by mAbcg2 (together: 12-fold). | quizartinib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |