Pub. Date : 2019 Mar 23
PMID : 30552945
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, we demonstrated that 3alpha-diol can protect neurons and neuronal-like cells against oxidative stress-induced neurotoxicity associated with prolonged phosphorylation of the extracellular signal-regulated kinase (ERK). | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Recently, we demonstrated that 3alpha-diol can protect neurons and neuronal-like cells against oxidative stress-induced neurotoxicity associated with prolonged phosphorylation of the extracellular signal-regulated kinase (ERK). | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | In the present study, we sought to determine whether the ERK-specific phosphatase, mitogen-activated protein kinase phosphatase 3/dual specificity phosphatase 6 (MKP3/DUSP6), is involved in the cytoprotective effects of 3alpha-diol in SH-SY5Y human female neuroblastoma cells. | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | 3alpha-diol inhibited ERK phosphorylation and ameliorated cell death induced by the oxidative stressor hydrogen peroxide (H2O2). | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | These findings suggest that the protective effects of 3alpha-diol are mediated through regulation of ERK phosphorylation in neurotoxic conditions and indicate that these effects may be exerted through modulation of MKP3/DUSP6. | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |