Pub. Date : 2019 Mar 15
PMID : 30552925
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to rapamycin. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 2 | Based on the well-described effects of mTORC1/rapamycin complex on 4E-BP1 phosphorylation/s, it is generally accepted that rapamycin is a global inhibitor of cap-dependent translation. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 3 | We have previously shown that 4E-BP1 resistance to rapamycin was overcome by the stoichiometric abundance of S6K1. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 4 | Now we present evidence that the TOS-bearing amino terminal domain of S6K1 is sufficient to relieve the rapamycin resistance of 4E-BP1 as TOS deleted variants of S6K1, active or inactive with regard to S6K1 activity failed to bring about relief of 4E-BP1 resistance to rapamycin. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 5 | The data presented in this study identifies eIF4E and not Raptor as a cellular factor responsible to regulate rapamycin sensitivity of 4E-BP1 suggesting that the phosphorylation dynamics and rapamycin sensitivity of 4E-BP1 and S6K1 are regulated independently. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |