PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30552925-0	2019	Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to rapamycin.	Sirolimus	82-91	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	63-69	
30552925-2	2019	Based on the well-described effects of mTORC1/rapamycin complex on 4E-BP1 phosphorylation/s, it is generally accepted that rapamycin is a global inhibitor of cap-dependent translation.	Sirolimus	46-55	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	67-73	
30552925-3	2019	We have previously shown that 4E-BP1 resistance to rapamycin was overcome by the stoichiometric abundance of S6K1.	Sirolimus	51-60	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	30-36	
30552925-4	2019	Now we present evidence that the TOS-bearing amino terminal domain of S6K1 is sufficient to relieve the rapamycin resistance of 4E-BP1 as TOS deleted variants of S6K1, active or inactive with regard to S6K1 activity failed to bring about relief of 4E-BP1 resistance to rapamycin.	Sirolimus	104-113	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	128-134	
30552925-6	2019	The data presented in this study identifies eIF4E and not Raptor as a cellular factor responsible to regulate rapamycin sensitivity of 4E-BP1 suggesting that the phosphorylation dynamics and rapamycin sensitivity of 4E-BP1 and S6K1 are regulated independently.	Sirolimus	110-119	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	135-141