Pub. Date : 2019 May
PMID : 30552702
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. | Acetaminophen | BCL2 binding component 3 | Mus musculus |
| 2 | PUMA deficiency suppressed APAP-induced mitochondrial dysfunction and release of cell death factors from mitochondria, and protected against APAP-induced hepatocyte necrosis and liver injury in mice. | Acetaminophen | BCL2 binding component 3 | Mus musculus |
| 3 | PUMA deficiency suppressed APAP-induced mitochondrial dysfunction and release of cell death factors from mitochondria, and protected against APAP-induced hepatocyte necrosis and liver injury in mice. | Acetaminophen | BCL2 binding component 3 | Mus musculus |
| 4 | Furthermore, a small-molecule PUMA inhibitor, administered after APAP treatment, mitigated APAP-induced hepatocyte necrosis and liver injury. | Acetaminophen | BCL2 binding component 3 | Mus musculus |
| 5 | Furthermore, a small-molecule PUMA inhibitor, administered after APAP treatment, mitigated APAP-induced hepatocyte necrosis and liver injury. | Acetaminophen | BCL2 binding component 3 | Mus musculus |
| 6 | Conclusion: Our results demonstrate that RIP1/JNK-dependent PUMA induction mediates AILI by promoting hepatocyte mitochondrial dysfunction and necrosis, and suggest that PUMA inhibition is useful for alleviating acute hepatotoxicity attributed to APAP overdose. | Acetaminophen | BCL2 binding component 3 | Mus musculus |
| 7 | Conclusion: Our results demonstrate that RIP1/JNK-dependent PUMA induction mediates AILI by promoting hepatocyte mitochondrial dysfunction and necrosis, and suggest that PUMA inhibition is useful for alleviating acute hepatotoxicity attributed to APAP overdose. | Acetaminophen | BCL2 binding component 3 | Mus musculus |