Pub. Date : 2019 Jan
PMID : 30551472
11 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 2 | This study was designed to investigate whether quercetin showed neuroprotection on central neurons against chronic high glucose through the enhancement of Nrf2/ARE/glyoxalase 1 (Glo-1) pathway. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 3 | Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 4 | Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 5 | Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 6 | Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 7 | Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3beta inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3beta activation pretreatment reversed the effects of quercetin on the protein expression of gamma-GCS in the HG condition. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 8 | Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3beta inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3beta activation pretreatment reversed the effects of quercetin on the protein expression of gamma-GCS in the HG condition. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 9 | In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 10 | In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||
| 11 | In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens | ||