Title : Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Pub. Date : 2019 Jun

PMID : 30549267






3 Functional Relationships(s)
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1 This study investigated the impact of SLCO1B1 genotype on pravastatin systemic exposure in children and adolescents with hypercholesterolemia. Pravastatin solute carrier organic anion transporter family member 1B1 Homo sapiens
2 Interindividual variability of pravastatin acid (PVA) exposure within SLCO1B1 genotype groups exceeded the approximately twofold difference in mean PVA exposure observed between SLCO1B1 genotype groups (P > 0.05, q > 0.10). Pravastatin solute carrier organic anion transporter family member 1B1 Homo sapiens
3 Interindividual variability of pravastatin acid (PVA) exposure within SLCO1B1 genotype groups exceeded the approximately twofold difference in mean PVA exposure observed between SLCO1B1 genotype groups (P > 0.05, q > 0.10). Pravastatin solute carrier organic anion transporter family member 1B1 Homo sapiens