Pub. Date : 2018 Dec
PMID : 30546415
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neuroprotective role of dexmedetomidine pretreatment in cerebral ischemia injury via ADRA2A-mediated phosphorylation of ERK1/2 in adult rats. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | The expression of ADRA2A and extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the primary cultured astrocytes and rat brain ischemic tissues was detected in the different conditions prior to and following Dex pretreatment using western blotting. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 3 | The expression of ADRA2A and extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the primary cultured astrocytes and rat brain ischemic tissues was detected in the different conditions prior to and following Dex pretreatment using western blotting. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 4 | Under the normal oxygen conditions, 500 ng/ml Dex pretreatment increased the expression of ADRA2A and phosphorylated (p)-ERK1/2 in the astrocytes compared with in the control group. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 5 | Similarly, compared with those prior to Dex treatment, the levels of ADRA2A and p-ERK1/2 in the brain ischemic tissues following Dex treatment were increased. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 6 | Similarly, compared with those prior to Dex treatment, the levels of ADRA2A and p-ERK1/2 in the brain ischemic tissues following Dex treatment were increased. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 7 | The levels of ADRA2A and p-ERK1/2 were 0.72+-0.23 and 0.66+-0.25 following Dex treatment, compared with 0.76+-0.22 and 0.31+-0.18, respectively, prior to Dex treatment. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 8 | The effect of Dex pretreatment increasing p-ERK1/2 expression was attenuated by AG1478 pretreatment. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 9 | In summary, Dex appeared to promote phosphorylation of ERK1/2 in astrocytes under H/R. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 10 | As a specific agonist of ADRA2A, Dex may activate phosphorylation of ERK1/2 via ADRA2A in astrocytes. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 11 | Thus, the neuroprotective role of Dex pretreatment against cerebral ischemic injury may function via ADRA2A-mediated phosphorylation of ERK1/2. | Dexmedetomidine | mitogen activated protein kinase 3 | Rattus norvegicus |