Pub. Date : 2018
PMID : 30538426
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway. | schizandrin B | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | We further discovered that these antioxidative effects of SchB were mediated through induction of Nrf2. | schizandrin B | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | Importantly, using molecular docking and molecular dynamic simulation, we identified that Keap1, an adaptor for the degradation of Nrf2, was a target of SchB. | schizandrin B | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |