Pub. Date : 2019 Feb
PMID : 30529759
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While JAG1-induced Hes1 and Hey1 expression levels were predictably decreased after DAPT (NOTCH inhibitor) treatment, JAG1-induced Runx2 and Ocn levels were surprisingly constant in the presence of DAPT, indicating that JAG1 effects in the CNC cells are independent of the canonical NOTCH pathway. | dapt | jagged 1 | Mus musculus |
| 2 | While JAG1-induced Hes1 and Hey1 expression levels were predictably decreased after DAPT (NOTCH inhibitor) treatment, JAG1-induced Runx2 and Ocn levels were surprisingly constant in the presence of DAPT, indicating that JAG1 effects in the CNC cells are independent of the canonical NOTCH pathway. | dapt | jagged 1 | Mus musculus |
| 3 | Pharmacologic inhibition of JAK2 phosphorylation, with and without DAPT treatment, upon JAG1 induction reduced ALP production and, Runx2 and Ocn gene expression. | dapt | jagged 1 | Mus musculus |