| Protein Name | jagged 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16449 |
| Gene Symbol | Jag1 |
| UniProt | Q9QXX0 (JAG1_MOUSE), Q3UVN4 (Q3UVN4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
81
Total Number of Articles : 76 |
Description |
jagged 1 |
| Gene Summary |
Enables Notch binding activity. Involved in several processes, including circulatory system development; nephron epithelium development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including ciliary body morphogenesis; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Jul 2025] |
| synonyms |
|
| Properties | |