Title : CYP3A4/5 Activity Probed with Testosterone and Midazolam: Correlation between Two Substrates at the Microsomal and Enzyme Levels.

Pub. Date : 2019 Jan 7

PMID : 30517006






1 Functional Relationships(s)
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1 Compared with TST, MDZ was found to correlate better with the content of CYP3A4/5 (no correlation vs 0.431) and CYP3A5 (no correlation vs 0.447), and huge variations in enzyme content existed among different genotypes, which explained the lower degree of correlation at the microsomal level. Midazolam cytochrome P450 family 3 subfamily A member 5 Homo sapiens