Title : CLINICAL-PATHOGENETICAL ROLE OF DYNAMICS OF CONCENTRATION OF INTERLEUKIN-6 DEPENDING ON POLYMORPHISM OF ITS GENE IN CONDUCTING ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C.

Pub. Date : 2018 Oct

PMID : 30516500






4 Functional Relationships(s)
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1 CLINICAL-PATHOGENETICAL ROLE OF DYNAMICS OF CONCENTRATION OF INTERLEUKIN-6 DEPENDING ON POLYMORPHISM OF ITS GENE IN CONDUCTING ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C. The study included 83 patients with CHC who received antiviral therapy according to the EASL 2016 recommendations on a 12-week peg-IFN+SOF+RBV schedule. Ribavirin interleukin 6 Homo sapiens
2 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. Ribavirin interleukin 6 Homo sapiens
3 In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNalpha + SOF + RBV. Ribavirin interleukin 6 Homo sapiens
4 The ineffectiveness of AVT according to the scheme peg-IFNalpha+SOF+RBV was associated with the presence of CG/GG genotypes and the highest concentration of IL-6 in the blood. Ribavirin interleukin 6 Homo sapiens