Title : Effect of glutathione S-transferase genetic polymorphisms on busulfan pharmacokinetics and veno-occlusive disease in hematopoietic stem cell transplantation: A meta-analysis.

Pub. Date : 2019 Jun

PMID : 30511436






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GSTA1*B and GSTM1 null genotypes significantly decreased CLIV of busulfan (standardized difference in means (SDM) = -1.103; P = 0.019 and SDM = -0.418; P = 0.002, respectively). Busulfan glutathione S-transferase alpha 1 Homo sapiens
2 GSTA1*B significantly increased AUCIV of busulfan (SDM = 0.832; P = 0.046), whereas GSTM1 did not (SDM = 0.155; P = 0.478). Busulfan glutathione S-transferase alpha 1 Homo sapiens
3 GSTA1 and GSTM1 genotypes affected CLIV of busulfan, but only GSTA1 affected AUCIV . Busulfan glutathione S-transferase alpha 1 Homo sapiens