Pub. Date : 2018 Dec
PMID : 30510142
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, downregulation of the NFkappaB gene signature, as opposed to BCR signature, was a common feature that underlies the response of MCL to both selinexor and ibrutinib. | ibrutinib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Meanwhile, unaltered NFkappaB was associated with ibrutinib resistance. | ibrutinib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Our data highlight the role of NFkappaB pathway in drug response to ibrutinib and selinexor and show the potential of using selinexor to prevent and overcome intrinsic ibrutinib resistance through NFkappaB inhibition. | ibrutinib | nuclear factor kappa B subunit 1 | Homo sapiens |