Title : Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin-1/Mechanistic Target of Rapamycin Complex 2 and 5'Adenosine Monophosphate-Activated Protein Kinase Signaling.

Pub. Date : 2019 Apr

PMID : 30506571






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Exposure of primary mouse hepatocytes and HepG2 cells to the CB1 R agonist arachidonyl-2"-chloroethylamide inhibited the expression of Sirtuin-1 (Sirt1) and Rictor, a component of mechanistic target of rapamycin complex 2 (mTORC2) and suppressed insulin-induced Akt phosphorylation at serine 473. arachidonyl-2-chloroethylamide cannabinoid receptor 1 Homo sapiens