Title : Targeted deletion of the aryl hydrocarbon receptor in dendritic cells prevents thymic atrophy in response to dioxin.

Pub. Date : 2019 Feb

PMID : 30499018






2 Functional Relationships(s)
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1 Finally, our results show that activation of the AhR in CD11c+ dendritic cells is directly responsible for TCDD-induced alterations in the development and differentiation of thymocytes, which results in thymic atrophy. Polychlorinated Dibenzodioxins integrin subunit alpha X Homo sapiens
2 Collectively, these results suggest that CD11c+ dendritic cells play a critical role in mediating TCDD-induced thymic atrophy and disruption of T lymphocyte development and differentiation in the thymus. Polychlorinated Dibenzodioxins integrin subunit alpha X Homo sapiens