| Protein Name | integrin subunit alpha X |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3687 |
| Gene Symbol | ITGAX |
| UniProt | P20702 (ITAX_HUMAN), H3BN02 (H3BN02_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
353
Total Number of Articles : 423 |
Description |
integrin subunit alpha X |
| Gene Summary |
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
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