Pub. Date : 2018 Nov 26
PMID : 30478403
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A biophysical study on the mechanism of interactions of DOX or PTX with alpha-lactalbumin as a delivery carrier. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 2 | In the present study, a variety of thermodynamic, spectroscopic, computational, and cellular techniques were applied to assess alpha-lactalbumin potential as a carrier for doxorubicin and paclitaxel. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 3 | According to isothermal titration calorimetry data, the interaction between alpha-lactalbumin and doxorubicin or paclitaxel is spontaneous and the K (M-1) value for the interaction of alpha-lactalbumin and paclitaxel is higher than that for doxorubicin. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 4 | According to isothermal titration calorimetry data, the interaction between alpha-lactalbumin and doxorubicin or paclitaxel is spontaneous and the K (M-1) value for the interaction of alpha-lactalbumin and paclitaxel is higher than that for doxorubicin. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 5 | According to isothermal titration calorimetry data, the interaction between alpha-lactalbumin and doxorubicin or paclitaxel is spontaneous and the K (M-1) value for the interaction of alpha-lactalbumin and paclitaxel is higher than that for doxorubicin. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 6 | According to isothermal titration calorimetry data, the interaction between alpha-lactalbumin and doxorubicin or paclitaxel is spontaneous and the K (M-1) value for the interaction of alpha-lactalbumin and paclitaxel is higher than that for doxorubicin. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 7 | Differential scanning calorimetry and anisotropy results indicated formation of alpha-lactalbumin complexes with doxorubicin or paclitaxel. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 8 | Based on Pace analysis to determine protein thermal stability, doxorubicin and paclitaxel induced higher and lower thermal stability in alpha-lactalbumin, respectively. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 9 | Besides, fluorescence lifetime measurements reflected that the interaction between alpha-lactalbumin with doxorubicin or paclitaxel was of static nature. | Doxorubicin | lactalbumin alpha | Homo sapiens |
| 10 | Therefore, the authors hypothesized that alpha-lactalbumin could serve as a carrier for doxorubicin and paclitaxel by reducing cytotoxicity and apoptosis which was demonstrated during our in vitro cell studies. | Doxorubicin | lactalbumin alpha | Homo sapiens |